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KMID : 0363720070400020107
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Korean Journal of Anatomy
2007 Volume.40 No. 2 p.107 ~ p.113
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Increased Expressions of eNBC and NHE1 in Ischemic Penumbra after Permanent Middle Cerebral Artery Occlusion
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Jung Yong-Wook
Park Jin-Seo
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Abstract
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We conducted a chronological and comparative analysis of the levels of the electrogenic Na+/HCO3 -cotransporter (eNBC) and Na+/H+ exchanger 1 (NHE1) on ischemic penumbra, using the rat model of permanent middle cerebral artery occlusion (pMCAO). Both eNBC and NHE1 levels were significantly higher in the ischemic penumbra from 3 h to 6 h after focal ischemia than in the sham-operated control group. The enhancement of eNBC and NHE1 production following focal ischemia may contribute to brain cell swelling or damage during ischemic penumbra through intracellular alkalinization and Na+ overload. Therefore, increases of eNBC and NHE1 in ischemic penumbra may play an important role in secondary brain cell damages following permanent focal ischemic insults.
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KEYWORD
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Ischemia, Penumbra, eNBC, NHE1
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